Manufacturing Specialist / Sr. Manufacturing Specialist– Downstream Processing (DSP)/ Drug Product

Siegfried seeks a Manufacturing Specialist for downstream processing of viral vectors in Schlieren, Switzerland. The role involves cGMP operations, technology transfer, and continuous improvement within a dynamic CDMO environment.

This position is dedicated to the execution of downstream processing activities within a current Good Manufacturing Practice (cGMP) setting. The specialist supports the production of gene therapies, cell therapies, and vaccines by managing chromatography, filtration, and purification steps. The role also plays a key part in technology transfer, troubleshooting, and driving operational excellence.

Responsibilities

• Carry out downstream processing tasks such as chromatography, filtration, tangential flow filtration (TFF), and ultrafiltration/diafiltration (UF/DF) while adhering to cGMP standards.
• Execute manufacturing procedures strictly following batch records, standard operating procedures (SOPs), and regulatory requirements.
• Set up, operate, and perform routine maintenance on manufacturing equipment.
• Handle manufacturing support duties including cleaning, buffer preparation, material handling, inventory control, and process monitoring.
• Assist in the transfer of new technologies and processes into the manufacturing environment.
• Identify and resolve process or equipment issues that arise during production runs.
• Participate in deviation investigations, root cause analyses, and the implementation of corrective and preventive actions (CAPA).
• Maintain accurate and timely GMP documentation and interact with electronic systems like MES, LIMS, and SAP.
• Engage in initiatives aimed at continuous improvement and operational excellence.
• Collaborate closely with Quality Assurance, Engineering, Process Development, and Analytical teams.

Requirements

• A Bachelor's degree in Biology, Biotechnology, Biochemistry, Chemical Engineering, or a related field with 3–6 years of experience, or a Master's degree with 1–3 years of relevant experience.
• Proven experience in biopharmaceutical, gene therapy, cell therapy, or viral vector manufacturing, with a specific focus on downstream processing.
• Practical, hands-on experience with chromatography, filtration, and TFF/UF-DF operations.
• Solid understanding of cGMP regulations, cleanroom protocols, aseptic processing techniques, and GMP documentation standards.
• Ability to write and maintain SOPs and work instructions.
• Fluent proficiency in English, both written and spoken.

Nice to have

• Prior experience in Drug Product manufacturing, including formulation, sterile filtration, and aseptic fill-finish operations.
• Familiarity with manufacturing systems such as MES, LIMS, or SAP.
• Knowledge of the German language.

What the company offers

• Competitive and attractive compensation package.
• 25 days of vacation leave and flexible working hours.
• Opportunities to develop diverse skills in a dynamic and fast-paced environment.
• The chance to see results quickly and enjoy creative freedom by joining early in the facility lifecycle.

About the company

Siegfried DINAMIQS is a Contract Development and Manufacturing Organization (CDMO) located in Schlieren-Zurich, Switzerland, specializing in the manufacturing of viral vector gene therapies. The company upholds high standards in safety, quality, and sustainability while fostering a collaborative and inclusive culture. As part of a rapidly expanding global organization, employees are encouraged to thrive and contribute to both collective success and individual growth.

• A workplace that values both collective success and individual contributions.
• A dynamic, diverse, and inclusive environment within one of the industry's most active CDMOs.
• Long-term opportunities for growth and making an impact in a rapidly expanding global company.
• A culture that empowers employees to thrive while maintaining high standards in safety, quality, and sustainability.