Sr Principal Eng - Process Engineering

Johnson & Johnson seeks a Principal Process Engineer in Schaffhausen to lead technical strategy for synthetic drug product manufacturing, focusing on OSD and bioavailability technologies within global supply chain projects.

This position sits within the Supply Chain Engineering function and is based in Schaffhausen, Switzerland, operating in a hybrid capacity. The role is responsible for defining early design inputs and technical strategies for synthetic drug product manufacturing processes, particularly within strategic capital projects.

Responsibilities

• Manage the intake, prioritization, and resolution of technical requests related to synthetics controlled bioburden drug product manufacturing across global sites.
• Provide domain expertise and lead early-phase process design for oral solid dose (OSD) products, covering both batch and continuous manufacturing platforms.
• Drive process design for bioavailability enhanced technologies, with a specific focus on amorphous solid dispersions (ASD) and spray drying.
• Promote standardization and platform approaches to ensure robust, fit-for-purpose process designs.
• Advise on key decisions regarding process, equipment, and technology selection for drug product manufacturing.
• Collaborate with R&D, MSAT, Quality, EHS, and Operations leads to align on technical strategies.
• Identify opportunities for harmonization and best-practice exchange to reduce duplication and accelerate time-to-market.
• Maintain connections with external networks, such as ISPE, to introduce innovative manufacturing solutions.
• Ensure all activities align with enterprise strategies, GMP requirements, and technology roadmaps.
• Partner with External Manufacturing teams to prioritize support and resolve issues for high-impact programs.

Requirements

• Master’s degree or equivalent experience in Engineering, Pharmaceutical Sciences, or a related field.
• At least 10 years of experience in synthetics controlled bioburden drug product manufacturing.
• Deep expertise in bioavailability enhanced technologies, including ASD and spray drying.
• Proven experience with OSD controlled bioburden manufacturing, including batch and continuous processes.
• Strong understanding of cGMP environments and regulatory expectations for controlled bioburden drug products.
• Track record of leading multi-functional teams and influencing technical decisions in global organizations.
• Ability to support early-phase design, detail design, start-up, and Commissioning & Qualification (C&Q) of controlled bioburden and aseptic equipment.
• Experience with inherently safe containment design for components with low exposure levels.
• Drive adoption of digital solutions for DP manufacturing, including real-time monitoring, advanced process control, and smart manufacturing.
• Fluency in written and spoken English.
• Willingness to travel up to 25% domestically and internationally.

Nice to have

• Aseptic capability.
• Additional languages such as Dutch, Spanish, or Italian.

What the company offers

• An inclusive work environment that values each individual.
• Significant opportunities to influence technology direction, standardization, and capability building across the network.

About the company

Johnson & Johnson is guided by its Credo and believes that health is everything. The company aims to build a world where complex diseases are prevented, treated, and cured. It is responsible to its employees worldwide, respecting their diversity and dignity while recognizing their merit.

• Guided by a strong ethical Credo.
• Committed to preventing, treating, and curing complex diseases.
• Values diversity, dignity, and merit among its global workforce.