Staff Mass Spectrometrist

The University of Zurich seeks a Senior Staff Mass Spectrometrist to manage and optimize mass spectrometry infrastructure, support complex biological analyses, and train researchers in Zürich.

This senior position focuses on the operation and maintenance of advanced mass spectrometry systems, including Orbitrap Astral instruments. The role supports diverse research initiatives by preparing biological samples, developing LC-MS methods, and ensuring data quality across collaborative projects.

Responsibilities

• Operate and maintain mass spectrometry infrastructure, including Orbitrap Astral instruments and supporting LC systems.
• Coordinate, prepare, and process biological samples for stable isotope tracing, metabolomics, epitranscriptomics, and other MS-omics analyses.
• Support implementation of automated sample preparation pipelines to increase throughput and improve reproducibility.
• Provide hands-on guidance and training of students and postdocs in the use of the instruments.
• Contribute to development and optimization of LC-MS methods for metabolite quantification, isotope enrichment, lipid profiling, and modified nucleotides.
• Perform routine instrument calibration, troubleshooting, and preventive maintenance independently.
• Support data acquisition as well as initial QC and processing pipelines.
• Perform MS data processing and analysis across applications and collaborative projects.
• Manage MS data across projects to ensure traceability, organization, and reproducibility.
• Help manage consumables, sample logistics, and platform documentation.

Requirements

• Expert (MSc or PhD) in analytical chemistry, biochemistry, or a related field.
• Solid practical experience with LC-MS/MS - ideally on Orbitrap-based instruments.
• Background in stable isotope tracing and/or metabolomics in a biological setting is strongly preferred.
• Interest in or experience with laboratory automation - liquid handling, automated sample prep, or scripted workflows.
• Curiosity about emerging technologies, particularly single-cell mass spectrometry, is a genuine plus.
• Methodical, detail-oriented, and comfortable troubleshooting complex instrument issues.
• Able to work independently and communicate clearly with researchers at all levels.
• Experience in a core facility, CRO, or research lab environment is valued.
• English required; German is a plus.

What the company offers

• Wide range of attractive offers for employees.

About the company

The University of Zurich is Switzerland's largest university with around 10,000 employees and 12 professional apprenticeship streams. The University offers an inspiring working environment on cutting-edge research and top-class education.

• The University offers an inspiring working environment on cutting-edge research and top-class education.