Postdoctoral Position: Mechanotyping of Complex Cellular Systems

ETH Zurich seeks a Postdoctoral researcher in Basel to mechanotype complex cellular systems using nanotechnology and systems biology approaches.

This position operates at the intersection of mechanobiology, nanotechnology, and quantitative biology. The successful candidate will characterize cellular mechanical states through independent, high-level research, with significant autonomy to design experimental pipelines that connect physical measurements to biological insights.

Responsibilities

• Perform quantitative mechanotyping of single cells, tissues, and multicellular structures such as organoids and spheroids.
• Develop and utilize nanotechnological platforms for sensing forces, manipulating samples, and determining mechanical phenotypes.
• Apply advanced cell biological methods, including live-cell imaging, super-resolution microscopy, and genetically encoded reporters.
• Integrate mechanical phenotypes with molecular, signaling, and transcriptional networks using systems biology strategies.
• Conduct quantitative modeling and data-driven analysis to understand multi-parameter cellular states.
• Employ high-throughput and multi-scale methods to connect mechanical properties with functional cellular outcomes.

Requirements

• PhD in biophysics, cell biology, systems biology, mechanical engineering, or a closely related discipline.
• Proven expertise in experimental biophysics, cell biology, or quantitative biology.
• Strong ability to communicate effectively and collaborate within a team.
• Capacity to work autonomously and manage complex, interdisciplinary research projects.

Nice to have

• Prior experience with live-cell imaging, force measurement techniques, or data analysis in biological contexts.

What the company offers

• A competitive salary and benefits package aligned with Swiss academic standards.
• Access to state-of-the-art research facilities and equipment.
• An opportunity to work in a vibrant, interdisciplinary research environment.

About the company

ETH Zurich is a globally leading university focused on science and technology, known for excellent education and cutting-edge fundamental research. The institution promotes independent thinking, equality of opportunity, diversity, and sustainability, while fostering an inclusive and supportive workplace that transfers new knowledge directly into society.

• Renowned for excellent education and cutting-edge fundamental research.
• Promotes independent thinking and an environment that inspires excellence.
• Committed to equality of opportunity, diversity, and sustainability.
• Fosters an inclusive and supportive workplace culture.