Sr. Scientist - Computational Biology - Neuroscience & Rare Diseases

Roche seeks a Senior Scientist in Computational Biology to analyze complex biological data for Neuroscience and Rare Diseases, identifying new therapeutic targets and biomarkers.

This position sits within the Computational Sciences Centre of Excellence, supporting Roche’s Research and Early Development units. The role focuses on the Neuroscience and Rare Diseases therapeutic area within the Computational Biology and Medicine department, aiming to uncover novel therapeutic targets and biomarkers through the analysis of high-dimensional data.

Responsibilities

• Analyze complex datasets, including single-cell, spatial, proteomics, metabolomics, and human genetics data, to aid in the development of therapies and biomarkers.
• Partner with AI and Machine Learning Foundation Model teams to apply advanced quantitative methods, supporting drug discovery initiatives in Neuroscience and Rare Diseases.
• Provide clear, objective, data-driven insights to guide portfolio decision-making processes.
• Help shape the data and analytics strategy for Neuroscience and Rare Diseases efforts in collaboration with therapeutic area partners.
• Build strong working relationships with key stakeholders, laboratory teams, and computational groups within the disease therapeutic area.
• Foster a collaborative workplace culture characterized by scientific rigor, continuous improvement, and open feedback.
• Support the professional growth of team members by sharing knowledge and expertise.

Requirements

• PhD in Bioinformatics, Biostatistics, Computational Biology, or a related field, with 3-5 years of relevant work experience preferred.
• Proven experience in disease biology.
• Demonstrated scientific impact through primary author publications in scientific journals.
• Proficiency in programming using R and/or Python.
• Working knowledge of a Linux/Unix environment and experience processing data on an HPC cluster.
• Knowledge and experience in Statistical and Machine Learning methods.
• Strong communication skills with the ability to present complex results clearly to both specialist and non-specialist audiences.
• Ability to work effectively in a collaborative, cross-functional scientific environment.

Nice to have

• Demonstrated experience in drug discovery and/or translational research is highly valued.
• Specific expertise in neurodegenerative diseases or neuro-immune interactions is a plus.

About the company

Roche is driven by a healthier future and aims to innovate to advance science. The company’s mission is to prevent, stop, and cure diseases while ensuring everyone has access to healthcare today and for generations to come. Key behaviors driving this mission include unwavering focus, collaborative teamwork, and exceptional delivery.

• The culture encourages personal expression, open dialogue, and genuine connections, where employees are valued, accepted, and respected.