PhD Position in Radiopharmaceutical Sciences: Glycoengineered Peptides and Nanobodies for Imaging and Therapy

ETH Zurich seeks a PhD candidate to research glycoengineered peptides and nanobodies for diagnostic and therapeutic applications in radiopharmaceutical sciences.

This position focuses on enhancing the biological and pharmacological performance of therapeutic and diagnostic agents through defined N-glycosylation. The role integrates advanced glycobiology, radiopharmaceutical sciences, and translational research to develop novel imaging and treatment strategies.

Responsibilities

• Create and refine methods for labeling glycosylated peptides and nanobodies with diagnostic and therapeutic radionuclides.
• Execute quality control measures and analytical characterization for new radiopharmaceutical products.
• Carry out cell-based assays to evaluate binding, uptake, and internalization processes.
• Design and analyze preclinical studies, including biodistribution, PET, and SPECT imaging in mouse models.
• Assess the pharmacokinetic and pharmacodynamic profiles of newly synthesized radiolabeled compounds.
• Collaborate closely with a PhD student in the Locher laboratory to design and optimize glycosylated peptide and nanobody constructs.
• Share research outcomes through presentations at international conferences and publications in peer-reviewed journals.

Requirements

• Hold a Master's degree with strong academic performance in Chemistry, Pharmaceutical Sciences, Biochemistry, Molecular Biology, Biotechnology, or a related field.
• Demonstrate a strong interest in radiopharmaceutical sciences, molecular imaging, protein engineering, glycobiology, or bioconjugation chemistry.
• Possess practical experience in at least one area: radiochemistry/radiopharmacy, cell biology/cell culture, protein/peptide chemistry, or preclinical in vivo research.
• Show excellent organizational abilities and problem-solving skills.
• Work effectively both independently and as part of an interdisciplinary, international team.
• Communicate fluently in English, both written and orally.

Nice to have

• Previous experience in radiopharmaceutical research, PET/SPECT imaging, or animal studies is advantageous but not mandatory.

What the company offers

• Contribute to cutting-edge bench-to-bedside radiopharmaceutical research and development.
• Access diverse professional and personal development opportunities, including training courses, workshops, conferences, and collaborations with leading experts.
• Benefit from attractive career growth prospects within an interdisciplinary research setting.
• Receive support, mentoring, and active knowledge sharing from experienced colleagues.
• Work with state-of-the-art research infrastructure in an innovative environment at a leading Swiss research institution.

About the company

ETH Zurich fosters an open, respectful, and international working culture that values diverse backgrounds, perspectives, and experiences. The institution emphasizes close collaboration within a motivated team, characterized by mutual support, individual responsibility, and a constructive feedback culture.

• Promotes an open and respectful international work environment.
• Values diverse backgrounds and perspectives.
• Encourages close collaboration and mutual support within the team.
• Fosters individual responsibility and constructive feedback.